bromfenac sodium salt sesquihydrate

Names

[ CAS No. ]:
120638-55-3

[ Name ]:
bromfenac sodium salt sesquihydrate

[Synonym ]:
Sodium (2-amino-3-(4-bromobenzoyl)phenyl)acetate
bromfenacum [INN_la]
Bromfenac monosodium salt sesquihydrate
Unii-8ecv571Y37
[2-Amino-3-(4-bromobenzoyl)phenyl]acetic acid
BroMfenac sodiuM 1.5H2O
Bromfenac Sodium Sesquihydrate
Bromfenac ophthalmic
Bromfenac ophthalmic solution
Benzeneacetic acid, 2-amino-3-(4-bromobenzoyl)-
bromfenac
Bromfenac sodium
Duract
Bromfenac (sodium hydrate)

Biological Activity

[Description]:

Bromfenac (sodium hydrate) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity(1) Bromfenac (sodium hydrate) (1 mg/kg, i.v.) is metabolited into an unusual conjugate, bromfenac N-glucoside, in rats bile(2) Bromfenac (sodium hydrate) permeation was found to be 1.62-fold higher through ChS-CS-NPs

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Kirkman SK et al. Isolation and identification of bromfenac glucoside from rat bile. Drug Metab Dispos. 1998 Jul;26(7):720-3.

[2]. Abdullah TA et al. Chondroitin sulfate-chitosan nanoparticles for ocular delivery of bromfenac sodium: Improved permeation, retention, and penetration. Int J Pharm Investig. 2016 Apr-Jun;6(2):96-105.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
562.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₂BrNO_3.3/₂H₂O_.Na

[ Molecular Weight ]:
383.17

[ Flash Point ]:
293.8±30.1 °C

[ PSA ]:
80.39000

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.663

[ Storage condition ]:
2-8℃

Related Compounds

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