SRTCX1002

Names

[ CAS No. ]:
1203479-63-3

[ Name ]:
SRTCX1002

[Synonym ]:
1H-Benzimidazole-7-carboxamide, 2-[3-(4-morpholinyl)phenyl]-N-2-thiazolyl-
2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide

Biological Activity

[Description]:

SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner.

[References]

References 1. Yang H, et al. PLoS One. 2012;7(9):e46364. 2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448. View Related Products by Target Sirtuin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₁₉N₅O₂S

[ Molecular Weight ]:
405.473

[ Exact Mass ]:
405.125946

[ LogP ]:
2.73

[ Index of Refraction ]:
1.732

Related Compounds

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