pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt

Names

[ CAS No. ]:
120298-73-9

[ Name ]:
pTH-Related Protein (1-40) (human, mouse, rat) trifluoroacetate salt

Biological Activity

[Description]:

pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1)[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Endocrinology

Signaling Pathways >> TGF-beta/Smad >> PKC

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀₇H₃₃₄N₆₆O₅₈

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Parathyroid hormone-related peptide stimulates proliferation of highly tumorigenic human SV40-immortalized breast epithelial cells.

J. Bone Miner Res. 15 , 2129-2139, (2000)

Parathyroid hormone-related protein (PTHrP) is the main mediator of humoral hypercalcemia of malignancy (HHM) and it is produced by many tumors, including breast cancers. Breast epithelial cells as we...

Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo.

Cancer Res. 57 , 3194-3199, (1997)

Humoral hypercalcemia of malignancy results from the effects of tumor-produced factors on bone, kidney, and intestine that disrupt normal calcium homeostasis. Although parathyroid hormone-related prot...

Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.

Domest. Anim. Endocrinol. 8 , 499-507, (1991)

The effects of transforming growth factor-alpha (TGF alpha) were determined on the ability of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP) to stimulate bone resorption and ...