(R)-N-METHYL-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE

Names

[ CAS No. ]:
119618-21-2

[ Name ]:
(R)-N-METHYL-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE

[Synonym ]:
Benzeneacetic acid,a-cyclohexyl-a-hydroxy-,4-(diethylamino)-2-butynyl ester,(aR)-(9CI)
(R)-A-PHENYLCYCLOHEXANEGLYCOLIC ACID 4-(DIETHYLAMINO)-2-BUTYNYL ESTER,HYDROCHLORIDE
[3H]-Oxybutynin
(R)-OXYBUTYNIN HCL
(R)-Oxybutynin
Benzeneacetic acid,a-cyclohexyl-a-hydroxy-,4-(diethylamino)-2-butynyl ester,(R)
(R)-Oxybutynin hydrochloride

Biological Activity

[Description]:

(R)-Oxybutynin (Aroxybutynin), a (R)-isomer of Oxybutynin, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antimuscarinic, antispasmodic and anticholinergic activity, competitively antagonizes Carbachol-induced contractions. (R)-Oxybutynin can be used for researching incontinence due to neurogenic bladder dysfunction[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[Target]

Muscarinic receptor, mAChR[1][2]

[References]

[1]. Smith ER, et al. Comparison of the antimuscarinic and antispasmodic actions of racemic oxybutynin and desethyloxybutynin and their enantiomers with those of racemic terodiline. Arzneimittelforschung. 1998 Oct;48(10):1012-8.

[2]. Siddiqui MA, et al. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004;64(8):885-912.

[3]. Zobrist RH, et al. Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharm Res. 2001 Jul;18(7):1029-34.

Chemical & Physical Properties

[ Melting Point ]:
52-54ºC

[ Molecular Formula ]:
C₂₂H₃₂ClNO₃

[ Molecular Weight ]:
393.94700

[ Exact Mass ]:
393.20700

[ PSA ]:
49.77000

[ LogP ]:
4.14490