CRANAD-2

Names

[ CAS No. ]:
1193447-34-5

[ Name ]:
CRANAD-2

[Synonym ]:
(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron

Biological Activity

[Description]:

CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Ran C, et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28;131(42):15257-61.

[2]. Ran C, et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29;6(4):e19362.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₅BF₂N₂O₂

[ Molecular Weight ]:
410.26500

[ Exact Mass ]:
410.19800

[ PSA ]:
32.78000

[ LogP ]:
4.93870

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble 0.2 mg/mL, clear (warmed)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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