N-Desmethyl zopiclone-d8

Names

[ CAS No. ]:
1189805-43-3

[ Name ]:
N-Desmethyl zopiclone-d8

Biological Activity

[Description]:

N-Desmethyl zopiclone-d8 is deuterium labeled Norzopiclone. Norzopiclone is the inactive metabolite of Zopiclone. Norzopiclone has some anxiolytic properties.

[Related Catalog]:

Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Sha Y, et al. Synthesis of RP 48497, an impurity of eszopiclone. Molecules. 2008 Aug 22;13(8):1817-21.

[3]. Thomas P. Jerussi, et al. Methods of making and using N-desmethylzopiclone. US 6339086 B1.

[4]. Tornio A, et al. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone. Eur J Clin Pharmacol. 2006 Aug;62(8):645-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H7D8ClN6O3

[ Molecular Weight ]:
382.83

Related Compounds