PKM2 activator 2
Names
[ CAS No. ]:
1186660-06-9
[ Name ]:
PKM2 activator 2
Biological Activity
[Description]:
PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells[1].
[Related Catalog]:
[Target]
PKM2:66 nM (EC50)
[In Vitro]
PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines [1]. PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H18F2N2O4S2
[ Molecular Weight ]:
452.49