Pindolol-d7

Names

[ CAS No. ]:
1185031-19-9

[ Name ]:
Pindolol-d7

[Synonym ]:
Apo-pindol
Pindolol-d7

Biological Activity

[Description]:

Pindolol-d7 (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33 nM)[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Artigas F, et al. Pindolol augmentation of antidepressant response. Curr Drug Targets. 2006;7(2):139-147.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H13D7N2O2

[ Molecular Weight ]:
255.36400

[ Exact Mass ]:
255.19600

[ PSA ]:
57.28000

[ LogP ]:
2.29650

Related Compounds