(S)-Lathosterol-d4

Names

[ CAS No. ]:
1182005-25-9

[ Name ]:
(S)-Lathosterol-d4

[Synonym ]:
(5α,6S,9β)-(1,2,5,6-H)Cholest-7-en-3-ol
Cholest-7-en-1,2,5,6-d-3-ol, (5α,6S,9β)-

Biological Activity

[Description]:

(S)-Lathosterol-d4 is the deuterium labeled (S)-Lathosterol. Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis[1].

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Kempen HJ, et al. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res. 1988 Sep;29(9):1149-55.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
479.5±44.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H42D4O

[ Molecular Weight ]:
390.68

[ Flash Point ]:
208.9±20.7 °C

[ Exact Mass ]:
390.379974

[ LogP ]:
9.76

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.525

Related Compounds