Duocarmycin analog-2

Names

[ Name ]:
Duocarmycin analog-2

Biological Activity

[Description]:

Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker

[In Vitro]

Duocarmycin analog-2 (72 h) has anti-proliferative activity with IC50 values of 0.001, 0.002, 0.002, 0.004, 0.009, 0.01, 0.015, 0.019, 0.019, 0.019, 0.02, 0.04, and 0.068 nM for DU4475, SET2, HCT 16, A2780, MDA MB468, LNCaP, LS174T, CCRF-CEM, COLO205, H2087, H661, A549, and MCD MB231 cells, respectively.

[References]

[1]. Chowdari NS, et, al. Enediyne compounds, conjugates thereof, and uses and methods therefor. WO2013122823A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₃ClN₄O₃

[ Molecular Weight ]:
510.97

Related Compounds

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