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Desmethylxanthohumol

Names

[ CAS No. ]:
115063-39-3

[ Name ]:
Desmethylxanthohumol

[Synonym ]:
Demethylxanthohumol
2',4',6',4-tetrahydroxy-3-C-prenylchalcone
2',4',6',4-tetrahydroxy-3'-prenylchalcone
2',4,4',6'-tetrahydroxy-3'-(3-methyl-2-butenyl)chalcone
Desmethylxanthohumol
(E)-3-(4-hydroxyphenyl)-1-[2,4,6-trihydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
2',4',6',4-tetrahydrooxy-3-C-prenylchalcone

Biological Activity

[Description]:

Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Yuou Teng, et al. Synthesis and Antioxidant Evaluation of Desmethylxanthohumol Analogs and Their Dimers. Eur J Med Chem. 2017 Jan 5;125:335-345.

[2]. Reinhard A.Diller, et al. 71-Desmethylxanthohumol from Hops, Chemistry and Biological Effects. Beer in Health and Disease Prevention, 2009, Pages 703-709.

Chemical & Physical Properties

[ Density]:
1.312g/cm3

[ Boiling Point ]:
570.7ºC at 760mmHg

[ Molecular Formula ]:
C20H20O5

[ Molecular Weight ]:
340.37000

[ Flash Point ]:
313ºC

[ Exact Mass ]:
340.13100

[ PSA ]:
97.99000

[ LogP ]:
3.91380

[ Vapour Pressure ]:
1.26E-13mmHg at 25°C

[ Index of Refraction ]:
1.679

[ Storage condition ]:
2-8℃

Precursor & DownStream

Precursor

DownStream

Related Compounds