MK-3901

Names

[ Name ]:
MK-3901

Biological Activity

[Description]:

MK-3901 is a potent, selective, orally active P2X3 antagonist with IC50 of 21 nM; demonstrates efficacy similar to that of naproxen, after 60 mg/kg (p.o.) administration with EC90 of approximately 3 uM in the rat CFA model of inflammatory pain.

[References]

References 1. Ginnetti AT, et al. Bioorg Med Chem Lett. 2018 May 1;28(8):1392-1396. View Related Products by Target P2X Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₄FN₅O₂

[ Molecular Weight ]:
481.531

Related Compounds

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