Pyrovalerone hydrochloride solution
Names
[ CAS No. ]:
1147-62-2
[ Name ]:
Pyrovalerone hydrochloride solution
[Synonym ]:
1-(4-methylphenyl)-2-pyrrolidin-1-ylpentan-1-one,hydrochloride
EINECS 214-556-9
1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride (1:1)
1-Pentanone, 1-(4-methylphenyl)-2-(1-pyrrolidinyl)-, hydrochloride (1:1)
Pyrovalerone hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
362.4ºC at 760mmHg
[ Melting Point ]:
171-174°C
[ Molecular Formula ]:
C16H24ClNO
[ Molecular Weight ]:
281.821
[ Flash Point ]:
127.3ºC
[ Exact Mass ]:
281.154633
[ PSA ]:
20.31000
[ LogP ]:
4.18210
[ Vapour Pressure ]:
1.93E-05mmHg at 25°C
[ Storage condition ]:
Controlled Substance, -20°C Freezer, Under Inert Atmosphere
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YV9100000
- CHEMICAL NAME :
- Valerophenone, 4'-methyl-2-(1-pyrrolidinyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 1147-62-2
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H23-N-O.Cl-H
- MOLECULAR WEIGHT :
- 281.86
- WISWESSER LINE NOTATION :
- T5NTJ AY3&VR D1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,871,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 261 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 360 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,294,1972
Safety Information
[ Symbol ]:
GHS05, GHS07, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H318-H411
[ Precautionary Statements ]:
P273-P280-P305 + P351 + P338
[ Hazard Codes ]:
Xn,T,F
[ Risk Phrases ]:
22-41-52-39/23/24/25-23/24/25-11
[ Safety Phrases ]:
26-39-45-36/37-16-7
[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution
[ RTECS ]:
YV9100000
[ HS Code ]:
2933910022
Customs
[ HS Code ]: 2933910022
Articles
Rev. Med. Chir. Soc. Med. Nat. Iasi. 115(4) , 1069-72, (2011)
To identify the risk factors for the use of ethnobotanicals and the people at risk to becoming users.This questionnaire basez objective population study included 89 subjects aged 14 to 42 years.19.10%...
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.J. Med. Chem. 49(4) , 1420-32, (2006)
Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation o...
Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry.Rapid Commun. Mass Spectrom. 24(18) , 2706-14, (2010)
A method for the toxicological screening of the new designer drug methylenedioxypyrovalerone (MDPV) is described; with an emphasis on its application for anti-doping analysis. The metabolism of MDPV w...