PVZB-1194

Names

[ Name ]:
PVZB-1194

[Synonym ]:
3'-Fluoro-4'-(trifluoromethyl)-4-biphenylsulfonamide
[1,1'-Biphenyl]-4-sulfonamide, 3'-fluoro-4'-(trifluoromethyl)-
3'-Fluoro-4'-(Trifluoromethyl)biphenyl-4-Sulfonamide

Biological Activity

[Description]:

PVZB-1194 is a bis(hetero)aryl derivative that inhibits kinesin spindle protein (KSP) ATPase witn IC50 of 0.12 uM; inhibits HeLa cell proliferation with IC50 of 5.5 uM; potently inhibits KSP in a microruble dependent manner and induces a monoastral phenotype to arrest mitotic progression, abnormal KSP localization.

[References]

References 1. Matsuno K, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. 2. Yokoyama H, et al. ACS Chem Biol. 2015 Apr 17;10(4):1128-36. View Related Products by Target Kinesin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
417.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₉F₄NO₂S

[ Molecular Weight ]:
319.275

[ Flash Point ]:
206.0±31.5 °C

[ Exact Mass ]:
319.029022

[ LogP ]:
3.26

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.536

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.