Sodium 4-hydroxybenzoate
Names
[ CAS No. ]:
114-63-6
[ Name ]:
Sodium 4-hydroxybenzoate
[Synonym ]:
Benzoic acid, 4-hydroxy-, sodium salt (1:1)
MFCD00016530
sodium p-hydroxybenzoate
sodium,4-hydroxybenzoate
4-Hydroxybenzoic acid,sodium salt
Sodium 4-hydroxybenzoate
p-hydroxybenzoic acid monosodium salt
EINECS 204-051-1
4-Hydroxybenzoic Acid Sodium Salt
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.375g/cm3
[ Boiling Point ]:
336.2ºC at 760mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C7H5NaO3
[ Molecular Weight ]:
160.103
[ Flash Point ]:
171.3ºC
[ Exact Mass ]:
160.013641
[ PSA ]:
60.36000
[ Vapour Pressure ]:
4.48E-05mmHg at 25°C
[ Storage condition ]:
Store at RT.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DH2900000
- CHEMICAL NAME :
- Benzoic acid, p-hydroxy-, sodium salt
- CAS REGISTRY NUMBER :
- 114-63-6
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C7-H5-O3.Na
- MOLECULAR WEIGHT :
- 160.11
- WISWESSER LINE NOTATION :
- QR DVO &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
DH2900000
[ HS Code ]:
2918290000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918290000
[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%
Articles
Bioorg. Med. Chem. Lett. 21 , 2521-6, (2011)
The inhibition of the β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of 25 branched aliphatic and aromatic...
Enzyme-catalyzed modification of PES surfaces: Reduction in adsorption of BSA, dextrin and tanninJ. Colloid. Interface Sci. 378(1) , 191-200, (2012)
Graphical abstract
p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells.Food Chem. Toxicol. 50(11) , 4109-14, (2012)
Parabens are among the most frequently used preservatives to inhibit microbial growth and extend the shelf life of a range of consumer products. The objective of the present study was to gain insight ...