MK-0941

Names

[ Name ]:
MK-0941

[Synonym ]:
3-(6-ethanesulfonylpyridin-3-yloxy)-5-((1S)-2-hydroxy-1-methyl-ethoxy)-N-(1-methyl-1H-pyrazol-3-yl)benzamide methanesulfonate
MK-0941

Biological Activity

[Description]:

MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Glucokinase

Research Areas >> Metabolic Disease

[Target]

EC50: 240 nM (Recombinant human glucokinase, 2.5 mM glucose), 65 nM (Recombinant human glucokinase, 10 mM glucose)[1]

[References]

[1]. Eiki J, et al. Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs. Mol Pharmacol. 2011 Dec;80(6):1156-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈N₄O₉S₂

[ Molecular Weight ]:
556.60900

[ Exact Mass ]:
556.13000

[ PSA ]:
203.77000

[ LogP ]:
4.15150

[ Storage condition ]:
-20℃

MK-0941

Names

Biological Activity

Chemical & Physical Properties

Related Compounds