HG-7-27-01

Names

[ Name ]:
HG-7-27-01

[Synonym ]:
N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-[(E)-2-(5-{[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino}-2-pyrazinyl)vinyl]benzamide
Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(E)-2-[5-[[2-methyl-6-(1-piperazinyl)-4-pyrimidinyl]amino]-2-pyrazinyl]ethenyl]-

Biological Activity

[Description]:

HG-7-27-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 224 nM, displays intermediate selectivity profiles (selectivity score=0.16) against 442 kinases.

[References]

References 1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. View Related Products by Target c-Fes Kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
754.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₇H₄₃F₃N₁₀O

[ Molecular Weight ]:
700.799

[ Flash Point ]:
409.8±32.9 °C

[ Exact Mass ]:
700.357361

[ LogP ]:
4.64

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds

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