WZ-4-49-8

Names

[ Name ]:
WZ-4-49-8

[Synonym ]:
N6-[4-(1,4'-Bipiperidin-1'-yl)-2-ethoxyphenyl]-N4-[2-(isopropylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, N6-(4-[1,4'-bipiperidin]-1'-yl-2-ethoxyphenyl)-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

Biological Activity

[Description]:

WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM; displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases; inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth; dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line.

[References]

References 1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40. 2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178. View Related Products by Target c-Fes Kinase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
856.4±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₂N₈O₃S

[ Molecular Weight ]:
618.793

[ Flash Point ]:
471.7±37.1 °C

[ Exact Mass ]:
618.310059

[ LogP ]:
3.45

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.648

Related Compounds

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