NecroX-7

Names

[ CAS No. ]:
1120333-38-1

[ Name ]:
NecroX-7

[Synonym ]:
5-[(1,1-Dioxido-4-thiomorpholinyl)methyl]-N-[1-(methylsulfonyl)-4-piperidinyl]-2-phenyl-1H-indol-7-amine
1H-Indol-7-amine, 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-N-[1-(methylsulfonyl)-4-piperidinyl]-2-phenyl-

Biological Activity

[Description]:

NecroX-7 is a small molecule necrosis modulator and potent antioxidant molecule, which can be bound to some types of radicals and especially NAPQI; inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression, reduces hepatic necrosis secondary to IR injury in vivo; decreases t-BHP- and APAP-induced cell death and ROS/RNS formation in HepG2 human hepatocarcinoma and primary mouse hepatocytes, also protects mice from APAP-induced liver injury and lethality by binding directly to NAPQI.

[References]

References 1. Choi JM, et al. Transplant Proc. 2010 Nov;42(9):3414-21. 2. Grootaert MO, et al. Atherosclerosis. 2016 Sep;252:166-74. 3. Lee DW, et al. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14. 4. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22. View Related Products by Target Apoptosis Inducer

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
806.2±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₉N₃O₃S

[ Molecular Weight ]:
516.676

[ Flash Point ]:
441.4±37.1 °C

[ Exact Mass ]:
516.186523

[ LogP ]:
2.23

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Storage condition ]:
2-8°C

Related Compounds

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