Amitivir

Names

[ Name ]:
Amitivir

[Synonym ]:
Amitivir (USAN/INN)
Amitivir
UNII-R4KR9A9165

Biological Activity

[Description]:

Amitivir (LY 217896), a thiadiazole derivative, possesses broad antiviral activity against orthomyxo- and paramyxoviruses. Amitivir is effective against influenza A and B viruses[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[In Vitro]

The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenza (A/Russia, A/Brazil/11/78, A/Ann Arbor/1/57, A/Port Chalmers/1/73, A/Hong Kong/8/68 and A/X-15) ranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus (B/Maryland/11/59, B/GreatLakes/1739/54, B/Singapore/3/64, B/Lee/40) ranged from 0.75 to 1.54 μg/ml[2].

[In Vivo]

Amitivir (LY 217896) (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus[2].

[References]

[1]. Hayden FG, et al. Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans. Antimicrob Agents Chemother. 1994;38(5):1178-1181.

[2]. Colacino JM, et al. Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt. Antimicrob Agents Chemother. 1990;34(11):2156-2163.

Chemical & Physical Properties

[ Density]:
1.613g/cm3

[ Boiling Point ]:
236.3ºC at 760mmHg

[ Molecular Formula ]:
C₃H₂N₄S

[ Molecular Weight ]:
126.14000

[ Flash Point ]:
96.7ºC

[ Exact Mass ]:
126.00000

[ PSA ]:
93.07000

[ Vapour Pressure ]:
0.0477mmHg at 25°C

[ Index of Refraction ]:
1.703

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.