L-penicillamine
Names
[ CAS No. ]:
1113-41-3
[ Name ]:
L-penicillamine
[Synonym ]:
EINECS 214-203-9
L(+)-Penicillamine
2-Amino-3-mercapto-3-methylbutanoic acid
3-mercapto-L-valine
3-Sulfanyl-L-valine
L-β,β-Dimethylcysteine
L-Penicillamine
(R)-penicillamine
(±)-penicillamine
DL-Penicillamine
β, β-Dimethyl-DL-cysteine
β,β-Dimethyl-DL-cysteine
L-β-Mercaptovaline
(2R)-2-amino-3-mercapto-3-methyl-butyric acid
(2R)-2-amino-3-mercapto-3-methylbutanoic acid
3,3-Dimethyl-DL-cysteine
3-Sulfanylvaline
MFCD00064303
Valine, 3-mercapto-
α-AMINO-β-METHYL-β-MERCAPTOBUTYRIC ACID
L-Valine, 3-mercapto-
H-Pen-OH
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
251.8±35.0 °C at 760 mmHg
[ Melting Point ]:
206ºC (dec.)
[ Molecular Formula ]:
C5H11NO2S
[ Molecular Weight ]:
149.211
[ Flash Point ]:
106.1±25.9 °C
[ Exact Mass ]:
149.051056
[ PSA ]:
102.12000
[ LogP ]:
0.93
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.528
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YV9445500
- CHEMICAL NAME :
- Valine, 3-mercapto-, L-
- CAS REGISTRY NUMBER :
- 1113-41-3
- BEILSTEIN REFERENCE NO. :
- 1722374
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C5-H11-N-O2-S
- MOLECULAR WEIGHT :
- 149.23
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 4 umol/plate
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 34,3725,1985 *** REVIEWS *** TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,465,1979
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
2
[ RTECS ]:
YV9445500
[ HS Code ]:
2930909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Neurogastroenterol. Motil. 26(10) , 1396-407, (2014)
Although opioids induce intestinal muscle contraction and provoke constipation, the intestinal region(s) that contribute to the constipation have remained unclear. We report here a region-specific res...
Inhibitors of bacterialN-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activityBioorg. Med. Chem. Lett. 19 , 6350-2, (2009)
A screen biased toward compounds containing zinc-binding groups (ZBG’s) delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including l-captopril (IC 50 = 3.3 μM, K i = 1....
Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis.Arch. Pharm. Res. 38 , 1477-87, (2015)
As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory ac...