2',2'-difluorodeoxycytidine 5'-triphosphate

Names

[ Name ]:
2',2'-difluorodeoxycytidine 5'-triphosphate

[Synonym ]:
A0Q7SO4OZE
gemcitabine triphosphate
Cytidine, 2'-deoxy-2',2'-difluoro-, 5'-(tetrahydrogen triphosphate)
2'-Deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate)

Biological Activity

[Description]:

Gemcitabine triphosphate (dFdCTP) is one of the two nucleoside metabolites of Gemcitabine (HY-17026) in cells. The other is active diphosphate (dFdDTP). Gemcitabine triphosphate can be used as a standard in radio-labeled probe imaging studies, to identify tumors sensitive to Gemcitabine, and to evaluate Gemcitabine uptake and retention by cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Shewach DS, et al. Gemcitabine and radiosensitization in human tumor cells. Invest New Drugs. 1996;14(3):257-63.

Chemical & Physical Properties

[ Density]:
2.4±0.1 g/cm3

[ Boiling Point ]:
797.7±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₄F₂N₃O₁₃P₃

[ Molecular Weight ]:
503.138

[ Flash Point ]:
436.2±35.7 °C

[ Exact Mass ]:
502.970764

[ LogP ]:
-4.54

[ Vapour Pressure ]:
0.0±6.4 mmHg at 25°C

[ Index of Refraction ]:
1.724

Related Compounds

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