Ouabain Octahydrate
Names
[ CAS No. ]:
11018-89-6
[ Name ]:
Ouabain Octahydrate
[Synonym ]:
Card-20(22)-enolide, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, (1β,3β,5β,11α)-
Ouabain a-L-rhamnoside
G-Strophanthin (JAN)
Strodival
4-[(1R,3S,5S,8R,9S,10R,11R,13R,14S,17R)-1,5,11,14-Tetrahydroxy-10-(hydroxymethyl)-13-methyl-3-{[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanone
Ouabain
Oubain
(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolid
Gratibain
(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide
(1b,3b,5b,11a)-3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide
Astrobain
OUABAIN OCTAHYDRATE
Purostrophan
EINECS 211-139-3
g-Strophanthin Octahydrate
Card-20(22)-enolide, 3-((6-deoxy-α-L-mannopyranosyl)oxy)-1,5,11,14,19-pentahydroxy-, (1β,3β,5β,11α)-
g-Strophantoside
MFCD00003688
Acocantherin
Gratus strophanthin
STROPHOPERM
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
838.2±65.0 °C at 760 mmHg
[ Melting Point ]:
260ºC
[ Molecular Formula ]:
C29H60O20
[ Molecular Weight ]:
584.653
[ Flash Point ]:
272.9±27.8 °C
[ Exact Mass ]:
584.283264
[ PSA ]:
280.44000
[ LogP ]:
-1.64
[ Appearance of Characters ]:
powder | white
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.655
[ Water Solubility ]:
H2O: 10 mg/mL cold | Soluble in water.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RN3850000
- CHEMICAL NAME :
- Ouabain octahydrate
- CAS REGISTRY NUMBER :
- 11018-89-6
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C29-H44-O12.8H2-O
- MOLECULAR WEIGHT :
- 728.89
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1Q CQ E1 IQ MQ QQ F- DT5OV EHJ& OO- BT6OTJ CQ DQ EQ F1 &QH 8
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1213 ug/kg
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 197,19,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3750 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 39,161,1993
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H331-H373
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P260-P304 + P340 + P312-P403 + P233
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R23/25
[ Safety Phrases ]:
S45
[ RIDADR ]:
UN 1544 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
RN3850000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
Biochem. Pharmacol. 92(3) , 494-8, (2014)
Cisplatin is the most widely used chemotherapeutics for cancer treatment, however, its administration is connected to inevitable adverse effects. Previous studies suggested that cisplatin is able to i...
A survey of detergents for the purification of stable, active human cystic fibrosis transmembrane conductance regulator (CFTR).Biochim. Biophys. Acta 1838(11) , 2825-37, (2014)
Structural knowledge of the cystic fibrosis transmembrane conductance regulator (CFTR) requires developing methods to purify and stabilize this aggregation-prone membrane protein above 1mg/ml. Startin...
Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.Biochem. Pharmacol. 90(4) , 367-78, (2014)
Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being th...