Piperazine
Names
[ CAS No. ]:
110-85-0
[ Name ]:
Piperazine
[Synonym ]:
PIPERAZINE CHIPS
Hexahydropyrazine
Pyrazine hexahydride
Trimetazidine Hydrochloride Impurity G
1,4-diazacyclohexane
1,4-piperazine
Diethylenediamine
Piperazine
1,4-Diazacyclohexan
EINECS 203-808-3
MFCD00005953
1,4-DIAZACYCLOHEXANE, CERTIFIED REFERENCE MATERIAL
1,4-Diazacyclohexane,Diethylenediamine
Trimetazidine Impurity G
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[References]
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
149.3±8.0 °C at 760 mmHg
[ Melting Point ]:
109-112 °C(lit.)
[ Molecular Formula ]:
C4H10N2
[ Molecular Weight ]:
86.136
[ Flash Point ]:
49.7±10.2 °C
[ Exact Mass ]:
86.084396
[ PSA ]:
24.06000
[ LogP ]:
-1.17
[ Vapour Pressure ]:
4.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.424
[ Stability ]:
Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
150 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TK7800000
- CHEMICAL NAME :
- Piperazine
- CAS REGISTRY NUMBER :
- 110-85-0
- BEILSTEIN REFERENCE NO. :
- 0102555
- LAST UPDATED :
- 199704
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C4-H10-N2
- MOLECULAR WEIGHT :
- 86.16
- WISWESSER LINE NOTATION :
- T6M DMTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Open irritation test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1967
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,862,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep Gastrointestinal - nausea or vomiting
- REFERENCE :
- 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,478,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity
- REFERENCE :
- TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1340 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5400 mg/m3/2H
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity
- REFERENCE :
- TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 15,116,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 1,542,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,635,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 7/16/1965 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND:TWA 1 mg/m3;STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.3 mg/m3);STEL 0.3 ppm (1 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84705 No. of Facilities: 132 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 2512 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84705 No. of Facilities: 435 (estimated) No. of Industries: 10 No. of Occupations: 25 No. of Employees: 8786 (estimated) No. of Female Employees: 2609 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314-H317-H334-H361fd
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R34;R42/43;R52/53
[ Safety Phrases ]:
S22-S26-S36/37/39-S45-S61
[ RIDADR ]:
UN 2579 8/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
TK7800000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2933599090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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