Omzotirome

Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379)[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Omzotirome (0.750 mg/ 100 g; i.p.) with high-fat diet rats have significantly less visceral adipose tissue (vs. HFD rats) and exhibit altered metabolism in two major tissues that are very active metabolically and exhibit increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats[1]. Omzotirome, a functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet (HFD)[1]. Animal Model: Male Wistar rats (8 weeks)[1] Dosage: 0.750 mg/ 100 g Administration: I.p. Result: With high-fat diet rats had significantly less visceral adipose tissue (vs. HFD rats) and exhibited altered metabolism in two major tissues that were very active metabolically and exhibited increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats.

[1]. WO2008149379

[2]. Cioffi F, et al. TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet. FASEB J. 2010;24(9):3451-3461.