(S)-CR8

Names

[ Name ]:
(S)-CR8

[Synonym ]:
HMS3229B15
3lq5
SLQ

Biological Activity

[Description]:

(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. K Bettayeb, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₉N₇O

[ Molecular Weight ]:
431.53300

[ Exact Mass ]:
431.24300

[ PSA ]:
104.01000

[ LogP ]:
3.75900

Related Compounds

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