ganoderic acid D

Names

[ Name ]:
ganoderic acid D

[Synonym ]:
Ganoderic-acid-D
Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)-
GanodericacidD
(7β)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid

Biological Activity

[Description]:

Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT3

[References]

[1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77.

[2]. Yue QX，et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
688.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₂O₇

[ Molecular Weight ]:
514.650

[ Flash Point ]:
384.1±28.0 °C

[ Exact Mass ]:
514.293030

[ PSA ]:
125.81000

[ LogP ]:
2.43

[ Vapour Pressure ]:
0.0±4.9 mmHg at 25°C

[ Index of Refraction ]:
1.559

Related Compounds

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