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Garcinone D

Names

[ CAS No. ]:
107390-08-9

[ Name ]:
Garcinone D

[Synonym ]:
1,3,6-Trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
Garcinone D
9H-Xanthen-9-one, 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-butenyl)-
9H-Xanthen-9-one, 1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-
1,3,6-Trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
9H-Xanthen-9-one,1,3,6-trihydroxy-8-(3-hydroxy-3-methylbutyl)-7-methoxy-2-(3-methyl-2-butenyl)

Biological Activity

[Description]:

Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> NF-κB >> Keap1-Nrf2
Signaling Pathways >> JAK/STAT Signaling >> STAT
Research Areas >> Neurological Disease

[Target]

p-STAT3


[References]

[1]. Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12.

Chemical & Physical Properties

[ Density]:
1.304

[ Boiling Point ]:
674.2±55.0 °C at 760 mmHg

[ Melting Point ]:
202-204 ºC

[ Molecular Formula ]:
C24H28O7

[ Molecular Weight ]:
428.475

[ Flash Point ]:
231.2±25.0 °C

[ Exact Mass ]:
428.183502

[ PSA ]:
120.36000

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.625

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

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