Aspartame acesulfame

Names

[ Name ]:
Aspartame acesulfame

[Synonym ]:
Benzoacenaphthylene
Acesulfame Aspartame Salt
4,5-Benzoacenaphthylene
Benz(e)acenaphthylene
acessulfame-aspartame

Biological Activity

[Description]:

Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Aspartame is composed of phenylalanine (an important role in neurotransmitter regulation), aspartic acid (an excitatory neurotransmitter in the central nervous system) and methanol[2].

[In Vivo]

Aspartame (4000 mg/kg bw/day; p.o.) shows no adverse effect in acute, subacute and chronic toxicity studies with aspartame, and its decomposition products, conducted in mice, rats, hamsters and dogs[1].

[References]

[1]. Magnuson BA, et, al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007;37(8):629-727.

[2]. Humphries P, et, al. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008 Apr;62(4):451-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₄N₂O₄

[ Molecular Weight ]:
262.26100

[ Exact Mass ]:
262.09500

[ PSA ]:
102.48000

[ LogP ]:
0.23880

Safety Information

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds

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