NS13001

Names

[ Name ]:
NS13001

Biological Activity

[Description]:

A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.

[References]

References 1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53. 2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. View Related Products by Target Potassium Channel

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄ClN₇

[ Molecular Weight ]:
339.787

Related Compounds

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