butadiene

MOLECULAR FORMULA :

C4-H6

MOLECULAR WEIGHT :

54.10

WISWESSER LINE NOTATION :

1U2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

2000 ppm/7H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

8000 ppm

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - cough

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5480 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

285 gm/m3/4H

TOXIC EFFECTS :

Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

270 gm/m3/2H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

25 pph/23M

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1000 ppm/6H/13W-I

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1000 ppm/6H/1Y-I

TOXIC EFFECTS :

Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2200 mg/m3/4H/17W-I

TOXIC EFFECTS :

Blood - leukopenia Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 ppm/6H/14W-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 ppm/6H/6W-I

TOXIC EFFECTS :

Blood - normocytic anemia Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 ppm/6H/24W-I

TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

100 mg/m3/4H/17W-I

TOXIC EFFECTS :

Immunological Including Allergic - decrease in cellular immune response Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

625 ppm/6H/61W

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Cardiac - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

625 ppm/6H/13W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Cardiac - tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1000 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8000 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Endocrine - thyroid tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8000 ppm/6H/15W-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

200 ppm/40W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8000 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

625 ppm/6H/65W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Eye) - tumors Cardiac - tumors

TYPE OF TEST :

TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

63 ppm/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

8000 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

500 ppm/6H

SEX/DURATION :

male 5 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

1000 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

DOSE :

1000 ppm/6H

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Specific locus test

TYPE OF TEST :

DNA damage

TYPE OF TEST :

DNA adduct

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Sister chromatid exchange

TYPE OF TEST :

Dominant lethal test

TYPE OF TEST :

Mutation in mammalian somatic cells

TYPE OF TEST :

Sperm Morphology

TYPE OF TEST :

Heritable translocation test

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Ovary

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 263,47,1991 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4.4 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,155,1986 IARC Cancer Review:Animal SUFFICENT EVIDENCE IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,237,1992 IARC Cancer Review:Human LIMITED EVIDENC IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,237,1992 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,155,1986 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 54,237,1992 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1000 ppm (2200 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,28,1971 OSHA PEL (Gen Indu):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1000 ppm (2200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 10 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 10 ppm (22 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 50 ppm (73 mg/m3);Carcinogen JAN 1993 OEL-FRANCE:TWA 10 ppm (36 mg/m3) JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-HUNGARY:STEL 10 mg/m3;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (110 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1000 ppm (2200 mg/m3) JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:STEL 100 mg/m3 JAN 1993 OEL-SWEDEN:TWA 10 ppm (20 mg/m3);STEL 20 ppm (40 mg/m3);Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (11 mg/m3);Carcinogen JAN 1993 OEL-TURKEY:TWA 1000 ppm (2200 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (22 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,3-BUTADIENE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 13410 No. of Facilities: 3086 (estimated) No. of Industries: 26 No. of Occupations: 71 No. of Employees: 66326 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 13410 No. of Facilities: 2201 (estimated) No. of Industries: 20 No. of Occupations: 34 No. of Employees: 51971 (estimated) No. of Female Employees: 1410 (estimated)