Cephalexin monohydrochloride
Names
[ CAS No. ]:
105879-42-3
[ Name ]:
Cephalexin monohydrochloride
[Synonym ]:
cephalexin hydrochloride monohydrate
Cembrandiol
Biological Activity
[Description]:
Cephalexin (Cefalexin) hydrochloride monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) hydrochloride monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) hydrochloride monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) hydrochloride monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2].
[Related Catalog]:
[In Vitro]
Cephalexin (Cefalexin) hydrochloride monohydrate (10 μg/mL) disrupts polymer peptidoglycan (PG) biogenesis by inactivating enzymes called penicillin-binding proteins (PBPs)[1]. Cephalexin (Cefalexin) hydrochloride monohydrate inhibits a broad spectrum of grampositive and gram-negative organisms with MIC values of 2, 2, 2, 2, 4, 4.4 and 5.7 μg/mL for Bacillus anthracis, Edwardsiella taFda, Vibrio cholera, Pasteurella multocida, Edwardsiella tarda, Alcaligenes sp and Proteus rettgeri, respectively[2].
[In Vivo]
Cephalexin (Cefalexin) hydrochloride monohydrate (0-50 mg/kg; p.o.; for 3.5 hours) has antibacterial activity in male Swiss-Webster mice with infected bacterial[2]. Animal Model: Male Swiss-Webster mice with infected bacterial[2] Dosage: 0-50 mg/kg Administration: Oral administration; for 3.5 hours Result: Had antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative species mice.
[References]
Chemical & Physical Properties
[ Density]:
1.5g/cm3
[ Boiling Point ]:
727.4ºC at 760mmHg
[ Molecular Formula ]:
C16H20ClN3O5S
[ Molecular Weight ]:
401.86500
[ Flash Point ]:
393.7ºC
[ Exact Mass ]:
401.08100
[ PSA ]:
150.75000
[ LogP ]:
2.66110
[ Vapour Pressure ]:
3.27E-22mmHg at 25°C
[ Index of Refraction ]:
1.699