Q94 hydrochloride

Names

[ CAS No. ]:
1052076-77-3

[ Name ]:
Q94 hydrochloride

[Synonym ]:
2-Benzyl-1-(4-chlorobenzyl)-1H-benzimidazole hydrochloride (1:1)
1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(phenylmethyl)-, hydrochloride (1:1)

Biological Activity

[Description]:

Q94 hydrochloride, a selective PAR1 antagonist (IC50=916 nM), can selectively block PAR1/Gαq interaction and signalling. Q94 hydrochloride blocks PAR1-mediated increases in both CCL2 mRNA and protein levels in a dose-dependent manner. Q94 hydrochloride also completely blocks thrombin-induced ERK1/2 and MLC phosphorylation[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)

[Target]

IC50: 916 nM (PAR1)[1].

[References]

[1]. Deng X, et al. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell. 2008 Jun;19(6):2520-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈Cl₂N₂

[ Molecular Weight ]:
369.29

[ Exact Mass ]:
368.084717

Related Compounds

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