Splenopentin diacetate

Names

[ Name ]:
Splenopentin diacetate

[Synonym ]:
SP-5 ACETATE SALT
SPLENOPENTIN ACETATE SALT
ARG-LYS-GLU-VAL-TYR ACETATE
Splenopentin diacetate
SPLENIN FRAGMENT 32-36 ACETATE SALT
SP-5,Splenin Fragment 32-36,Splenopentin
ARG-LYS-GLU-VAL-TYR ACETATE SALT

Biological Activity

[Description]:

Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity[2]. Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells[3].

[In Vivo]

Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice[4]. Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice[3]. Animal Model: Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days[4] Dosage: 1 mg/kg Administration: I.p. three times a week for 7-90 days Result: Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment. Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.

[References]

[1]. Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68.

[2]. Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5.

[3]. Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9.

[4]. Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9.