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Cabotegravir Sodium

Names

[ CAS No. ]:
1051375-13-3

[ Name ]:
Cabotegravir Sodium

[Synonym ]:
S-265744B
Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, sodium salt, (3S,11aR)- (1:1)
3L12PT535M
CABOTEGRAVIR SODIUM
Sodium (3S,11aR)-8-[(2,4-difluorobenzyl)carbamoyl]-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazin-6-olate
GSK1265744B

Biological Activity

[Description]:

Cabotegravir sodium is a highly potent HIV integrase inhibitor with an IC50 value of 2.5 nM for HIVADA. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral drugs (ARVs)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase

[Target]

IC50: 2.5 nM (HIVADA)[1]


[References]

[1]. Zhou T, et al. Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials. 2018 Jan;151:53-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16F2N3NaO5

[ Molecular Weight ]:
427.334

[ Exact Mass ]:
427.095581

Related Compounds