NAAD sodium salt

Names

[ Name ]:
NAAD sodium salt

[Synonym ]:
Nicotinic acid NAD
Deamido NAD
Nicotinic acid adenine dinucleotide sodium salt
NAAD

Biological Activity

[Description]:

NAAD sodium salt (Deamido nad sodium salt), a functional NAD+ precursor, is the substrate of glutamine-dependent NAD+ synthetase. NAAD sodium salt is used to study the structure of nicotinate mononucleotide adenylyltransferases[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

In peripheral blood mononuclear cells (PBMC), NAAD is only expected to be produced in biosynthesis of NAD+ from tryptophan and NA2, was elevated from less than 20 nM to as high as 0.91 μM[1]. Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD)[2].

[In Vivo]

In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340 pmol/mg) in 15 min. Hepatic NA appearance is followed by an expected peak of 220 NAAD at 1 h post gavage and a rise in hepatic NAD+ from 990 baseline to 2200 at 2 h[1]. NAAD is reported in mouse liver when 500 mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD is observed in kidneys, ovaries, lung, heart and brain in addition to liver in mice IP-injected with 500 mg/kg of NA but not Nam[1].

[References]

[1]. Samuel A J Trammell, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948.

[2]. J Biol Chem. 2005 Apr 15;280(15):15131-40. Ralf Jauch, et al. Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₅N₆NaO₁₅P₂

[ Molecular Weight ]:
686.39

[ Exact Mass ]:
686.07500

[ PSA ]:
337.75000

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.

Mol. Cell. 17 , 855-868, (2005)

Sir2 enzymes form a unique class of NAD(+)-dependent deacetylases required for diverse biological processes, including transcriptional silencing, regulation of apoptosis, fat mobilization, and lifespa...

Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD.

Structure 10 , 69-79, (2002)

Nicotinamide/Nicotinate mononucleotide (NMN/NaMN) adenylyltransferase is an indispensable enzyme in both de novo biosynthesis and salvage of NAD+ and NADP+. In prokaryotes, it is absolutely required f...

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.

Biochemistry 42 , 9249-9256, (2003)

Life span regulation and inhibition of gene silencing in yeast have been linked to nicotinamide effects on Sir2 enzymes. The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene ...

Related Compounds

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