4-O-Methylsappanol

Names

[ Name ]:
4-O-Methylsappanol

[Synonym ]:
4-O-Methyl-sappanol
2H-1-Benzopyran-3,7-diol, 3-[(3,4-dihydroxyphenyl)methyl]-3,4-dihydro-4-methoxy-, (3R,4S)-
1,2,5-trideoxy-1,5-imino-D-erythritol
(3R,4S)-3-(3,4-Dihydroxybenzyl)-4-methoxy-3,7-chromanediol
cis-Piperidin-3,4-diol

Biological Activity

[Description]:

4-O-Methylsappanol is a natural isoflavonoid with antifungal activities. 4-O-Methylsappanol shows activity against Beauveria bassiana[1]. 4-O-Methylsappanol (EC50 of 4.6 µM) strongly suppresses Melanin (Melanin) synthesis in HMV-II cells[2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

4-O-Methylsappanol 对 HMV-II 细胞显示出中等的细胞毒性，IC50 值为 20.2 µM[2]。

[References]

[1]. V L Niranjan Reddy, et al. Inhibitory activity of homoisoflavonoids from Caesalpinia sappan against Beauveria bassiana. Fitoterapia. 2003 Sep;74(6):600-2.

[2]. Kaoru Mitani, et al. Suppression of melanin synthesis by the phenolic constituents of sappanwood (Caesalpinia sappan). Planta Med. 2013 Jan;79(1):37-44.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
564.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₈O₆

[ Molecular Weight ]:
318.321

[ Flash Point ]:
294.9±30.1 °C

[ Exact Mass ]:
318.110352

[ PSA ]:
99.38000

[ LogP ]:
1.19

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.691

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds

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