6-O-α-Maltosyl-β-cyclodextrin

Names

[ Name ]:
6-O-α-Maltosyl-β-cyclodextrin

[Synonym ]:
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5-({[(2S,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S ;,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}methyl)-10,15,20,25,30,35-hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxao 
ctacyclo[31.2.2.2.2.2.2~18
6-O-α-D-Maltosyl-β-cyclodextrin
6-O-Alpha-D-Maltosyl-Beta-cyclodextrin
6-O-Alpha-Maltosyl-Beta-cyclodextrin
MFCD00678869
MALTOSYL CYCLODEXTRIN
6-O-A-maltosyl-B-cyclodextrin hydrate
6-O-α-Maltosyl-β-cyclodextrin hydrate
6-O-α-Maltosyl-β-cyclodextrin

Biological Activity

[Description]:

6-O-α-Maltosyl-β-cyclodextrin is a cellular cholesterol modifier which can form soluble inclusion complex with cholesterol.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Biochemical Assay Reagents

Research Areas >> Others

[In Vitro]

6-O-α-Maltosyl-β-cyclodextrin (Mal-βCD) removes cellular cholesterol forming inclusion complexes, while 6-O-α-Maltosyl-β-cyclodextrin-induced lack of cellular cholesterol is replenished by the addition of cholesterol/6-O-α-Maltosyl-β-cyclodextrininclusion complex (CLM) without cytotoxicity[1].

[References]

[1]. Okada Y, et al. Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Carbohydr Res. 2012 Aug 1;357:68-74.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Molecular Formula ]:
C₅₄H₉₀O₄₅

[ Molecular Weight ]:
1459.265

[ Exact Mass ]:
1458.475464

[ PSA ]:
712.35000

[ LogP ]:
-9.19

[ Index of Refraction ]:
1.719

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Comparative study on inclusion complexation of maltosyl-beta-cyclodextrin, heptakis(2,6-di-O-methyl)-beta-cyclodextrin and beta-cyclodextrin with fucosterol in aqueous and solid state.

J. Pharm. Pharmacol. 45 , 1028, (1993)

The complexation of fucosterol with three kinds of beta-cyclodextrin (beta-CyD) was investigated in aqueous solution and in the solid state. The solubility of fucosterol increased significantly on its...

Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells.

Carbohydr. Res. , (2012)

We have previously described 6-O-α-maltosyl-β cyclodextrin (Mal-βCD), which forms soluble inclusion complex with cholesterol. Here we further investigated the effect of Mal-βCD and cholesterol/Mal-βCD...

N.m.r. study on the formation and geometry of inclusion complexes of 6-O-(alpha-maltosyl)cyclomalto-hexaose and -heptaose with p-nitrophenol in aqueous solution.

Carbohydr. Res. 226(2) , 197-208, (1992)

The formation and molecular geometry of inclusion complexes of some branched cyclomaltaoses with p-nitrophenol in aqueous solution have been investigated by using high-resolution 1H-n.m.r. spectroscop...