Ethylenediaminetetraacetic acid sodium hydrate

Names

[ Name ]:
Ethylenediaminetetraacetic acid sodium hydrate

[Synonym ]:
Ethylenediaminetetraacetic acid tetrasodium salt
Sodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate hydrate (4:1:2)
Ethylenediaminetetraacetic Acid Tetrasodium Salt Dihydrate
EDTA 4Na Dihydrate
Tetrasodium ethylenediaminetetraacetate dihydrate
Sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate hydrate (4:1:2)
EDTA-4Na.2H2O
EDTA tetrasodium salt
EINECS 208-924-8
MFCD00007499

Biological Activity

[Description]:

Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can also decrease the formation of disulfide bonds[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9.

[2]. Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76.

[3]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62.

Chemical & Physical Properties

[ Boiling Point ]:
614.2ºC at 760mmHg

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₁₀H₁₆N₂Na₄O₁₀

[ Molecular Weight ]:
416.201

[ Flash Point ]:
325.2ºC

[ Exact Mass ]:
416.039581

[ PSA ]:
185.46000

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
H2O: clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DB6145180

[ HS Code ]:
29224995

Articles

Treatment of glioma by cisplatin-loaded nanogels conjugated with monoclonal antibodies against Cx43 and BSAT1.

Drug Deliv. 22 , 276-85, (2015)

Targeted drug delivery for brain tumor treatment is one of the important objectives in nanomedicine. Human glioblastoma is the most frequent and aggressive type of brain tumors. The preferential expre...

Inhibition of in vitro fertilizing capacity of cryopreserved mouse sperm by factors released by damaged sperm, and stimulation by glutathione.

PLoS Biol. 5 , e9387, (2010)

In vitro fertilization (IVF) of eggs by frozen and thawed C57BL/6J mouse sperm is inhibited by dead sperm and enhanced by preincubation of the sperm in calcium-free medium. In other species, the prese...

Bi-allelic gene targeting in mouse embryonic stem cells.

Methods 53 , 331-8, (2011)

The EUCOMM and KOMP programs have generated targeted conditional alleles in mouse embryonic stem cells for nearly 10,000 genes. The availability of these stem cell resources will greatly accelerate th...