d(+)fructofuranose 1,6-diphosphate tetra(cyclohexylammonium) salt

[ Molecular Formula ]:
C₆H₂₆N₄O₁₂P₂

[ Molecular Weight ]:
408.23800

[ Exact Mass ]:
408.10200

[ PSA ]:
242.22000

[ LogP ]:
0.11440

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Click to get detail synthetic route

Precursor

DownStream

Fructose-1,6-bisphosphate attenuates induction of nitric oxide synthase in microglia stimulated with lipopolysaccharide.

Life Sci. 90(9-10) , 365-72, (2011)

Fructose-1,6-bisphosphate (FBP) is a glycolytic intermediate with neuroprotective action in various brain injury models. However, the mechanism underlying the neuroprotection of FBP has not been fully...

Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.

Handbook of Experimental Pharmacology 203 , 279-301, (2011)

Fructose-1,6-bisphosphatase (FBPase), a rate-controlling enzyme of gluconeogenesis, has emerged as an important target for the treatment of type 2 diabetes due to the well-recognized role of excessive...

Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.

Diabetes 55 , 1747-1754, (2006)

Gluconeogenesis is increased in type 2 diabetes and contributes significantly to fasting and postprandial hyperglycemia. We recently reported the discovery of the first potent and selective inhibitors...

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