NSC-12

Names

[ Name ]:
NSC-12

[Synonym ]:
21-(Hydroxy(bistrifluoromethyl)methyl)pregnane-3,20-diol
Pregn-5-ene-3,20-diol,21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)
NSC-12

Biological Activity

[Description]:

NSC 12 is an extracellular trap of fibroblast growth factor 2 (FGF2) that binds FGF2 and interferes with its interaction with FGFR1. NSC12 inhibits the proliferation of different FGF-dependent tumour cells both in vitro and in vivo with no systemic toxic effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Ronca R, et al. Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy. Cancer Cell. 2015 Aug 10;28(2):225-39.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₄F₆O₃

[ Molecular Weight ]:
484.51500

[ Exact Mass ]:
484.24100

[ PSA ]:
60.69000

[ LogP ]:
5.53300

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4816000

CHEMICAL NAME :: Pregn-5-ene-3,20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)-

CAS REGISTRY NUMBER :: 102586-30-1

LAST UPDATED :: 198612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H34-F6-O3

MOLECULAR WEIGHT :: 484.58

WISWESSER LINE NOTATION :: L E5 B666 MUTJ A1 E1 FYQ1XQXFFFXFFF OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#09324