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Valbenazine

Names

[ CAS No. ]:
1025504-45-3

[ Name ]:
Valbenazine

[Synonym ]:
Ingrezza
(2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl L-valinate
NBI-98854
L-Valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester
UNII:54K37P50KH
(2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-yl L-valinate
Valbenazine

Biological Activity

[Description]:

Valbenazine is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy, and inhibits VMAT2 function.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Valbenazine shows a distinctive improvement in tardive dyskinesia symptoms during the successful Phase II trial[1].

[References]

[1]. Müller T, et al. Valbenazine granted breakthrough drug status for treating tardive dyskinesia. Expert Opin Investig Drugs. 2015 Jun;24(6):737-42.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
507.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H38N2O4

[ Molecular Weight ]:
418.569

[ Flash Point ]:
260.6±30.1 °C

[ Exact Mass ]:
418.283173

[ PSA ]:
74.02000

[ LogP ]:
4.31

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.548

[ Storage condition ]:
2-8℃

Related Compounds