NS-3-008 hydrochloride

Names

[ Name ]:
NS-3-008 hydrochloride

[Synonym ]:
Guanidine, N-hexyl-N''-(phenylmethyl)-
2-Benzyl-1-hexylguanidine

Biological Activity

[Description]:

NS-3-008 hydrochloride is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).

[References]

References 1. Matsunaga N, et al. EBioMedicine. 2016 Nov;13:262-273. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
356.0±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₃N₃

[ Molecular Weight ]:
233.352

[ Flash Point ]:
169.1±25.9 °C

[ Exact Mass ]:
233.189194

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.528

Related Compounds

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