Tyrosine kinase inhibitor

Names

[ CAS No. ]:
1021950-26-4

[ Name ]:
Tyrosine kinase inhibitor

[Synonym ]:
N-(4-fluorophenyl)-N'-(4-{[2-({[2-(4-morpholinyl)ethyl]amino}carbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)-1,1-cyclopropanedicarboxamide
cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phenyl}amide (4-fluorophenyl)amide
XL184-Supplied by Selleck Chemicals
S1119_Selleck
CS-0524
Tyrosine kinase inhibitor

Biological Activity

[Description]:

A Tyrosine kinase inhibitor.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

Research Areas >> Cancer

[References]

[1]. Inoue T, et al. Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma. World J Surg Oncol. 2012 Aug 20;10(1):167.

[2]. Bowen JM, et al. Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea. Cancer Biol Ther. 2012 Nov 1;13(13).

[3]. Sun FK, et al. Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma. Chin Med J (Engl). 2012 Jun;125(12):2231-4.

[4]. Thamm DH. Tyrosine kinase inhibitor special issue. Vet Comp Oncol. 2012 Sep;10(3):161-2. doi: 10.1111/j.1476-5829.2012.00339.x.

[5]. Eriksson A, et al. The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia. Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.

[Related Small Molecules]

Capmatinib (INCB28060) | Foretinib (GSK1363089) | PHA-665752 | BMS-777607 | Dihexa | Savolitinib | Tivantinib (ARQ 197) | tepotinib | LY2801653 | SGX-523 | DCC-2618 | SU11274 | Ensartinib | CEP-40783 | JNJ-38877605

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₃₁FN₆O₅

[ Molecular Weight ]:
586.61300

[ Exact Mass ]:
586.23400

[ PSA ]:
137.68000

[ LogP ]:
4.38850

[ Storage condition ]:
2-8℃

Related Compounds

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