Oxcarbazepine-D4

Names

[ CAS No. ]:
1020719-71-4

[ Name ]:
Oxcarbazepine-D4

[Synonym ]:
Oxacarbazepine-d4
[2H4]-Oxcarbazepine
Oxetol-d4
Oxecarb-d4
Oxcarbazepine-D4 (Major)
Trileptal-d4
Aurene-d4

Biological Activity

[Description]:

Oxcarbazepine-D4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9.

[3]. Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53.

[4]. M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H12N2O2

[ Molecular Weight ]:
252.26800

[ Exact Mass ]:
252.09000

[ PSA ]:
63.40000

[ LogP ]:
3.40750

Related Compounds