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Pirfenidone D5

Names

[ CAS No. ]:
1020719-62-3

[ Name ]:
Pirfenidone D5

[Synonym ]:
Pirfenidone-d5
5-Methyl-N-phenyl-2-1H-pyridone-d5

Biological Activity

[Description]:

Pirfenidone D5 (AMR69 D5) is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CCR
Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Signaling Pathways >> Immunology/Inflammation >> CCR
Research Areas >> Inflammation/Immunology

[Target]

TGF-β2[1][2] CCL2 and CCL12[3]


[References]

[1]. Burghardt I, et al. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7.

[2]. Nakazato H, et al. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85.

[3]. Inomata M, et al. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res. 2014 Feb 8;15:16.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H6D5NO

[ Molecular Weight ]:
190.25300

[ Exact Mass ]:
190.11500

[ PSA ]:
22.00000

[ LogP ]:
2.14590

Related Compounds