KCNQ2/3 activator-1

Names

[ Name ]:
KCNQ2/3 activator-1

[Synonym ]:
Butanamide, N-[4-(6-fluoro-3,4-dihydro-2(1H)-isoquinolinyl)-2,6-dimethylphenyl]-3,3-dimethyl-
N-[4-(6-Fluoro-3,4-dihydro-2(1H)-isoquinolinyl)-2,6-dimethylphenyl]-3,3-dimethylbutanamide

Biological Activity

[Description]:

KCNQ2/3 activator-1 is an activator of Kv7.2/Kv7.3 (KCNQ2/3) potassium channel. KCNQ2/3 activator-1 has the potential in relieving pain (the main problem from medical treatment) (extracted from patent WO2021113757A1, compound A)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. James Philip, et al. Use of a kv7 potassium channel opener for treating pain. Patent WO2021113757A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
541.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₉FN₂O

[ Molecular Weight ]:
368.488

[ Flash Point ]:
281.4±30.1 °C

[ Exact Mass ]:
368.226379

[ LogP ]:
5.28

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.579

[ Storage condition ]:
-20°C

Related Compounds

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