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UNII:R99EE080JS

Names

[ CAS No. ]:
100324-80-9

[ Name ]:
UNII:R99EE080JS

[Synonym ]:
(S)-Lisofylline
UNII:R99EE080JS
Amendol
1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-
1-[(5S)-5-Hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Di-O-methyl-osajetin
1H-Purine-2,6-dione, 3,7-dihydro-1-[(5S)-5-hydroxyhexyl]-3,7-dimethyl-
1-(5-Hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Biological Activity

[Description]:

(S)-Lisofylline ((S)-Lisophylline)) is a kind of lisofline (LSF) enantiomer with optical activity. (S)-Lisofylline can interconversion with pentoxifylline[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

(S)-Lisofylline 在人溶血红细胞中能与己酮可可碱相互转化[2]。

[In Vivo]

(S)-Lisofylline (50 mg/kg；静脉注射；单剂量) 在小鼠肝脏、肾脏和肺部中显示出较高的含量，但在血清中含量较低[2]。

[References]

[1]. Borowiecki P, et al. Chemoenzymatic deracemization of lisofylline catalyzed by a (laccase/TEMPO)-alcohol dehydrogenase system[J]. Catalysis Science & Technology, 2022, 12(13): 4312-4324.

[2]. Wyska E, et al. Interconversion and tissue distribution of pentoxifylline and lisofylline in mice. Chirality. 2006 Aug;18(8):644-51.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
511.2±56.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H20N4O3

[ Molecular Weight ]:
280.323

[ Flash Point ]:
263.0±31.8 °C

[ Exact Mass ]:
280.153534

[ PSA ]:
82.05000

[ LogP ]:
0.34

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.621

Related Compounds