Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B.
S Morimoto, T Adachi, Y Misawa, T Nagate, Y Watanabe, S Omura
Index: J. Antibiot. 43(5) , 544-9, (1990)
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Abstract
6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.
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