BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

Modify Date: 2024-04-03 17:04:35

BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride Structure
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride structure
Common Name BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride
CAS Number 2691796-83-3 Molecular Weight 780.18
Density N/A Boiling Point N/A
Molecular Formula C41H45Cl3N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride


BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PD-1/PD-L1 degrader-1.html" class="link-product" target="_blank">PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].

 Names

Name BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride

  Biological Activity

Description BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PD-1/PD-L1 degrader-1.html" class="link-product" target="_blank">PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
Related Catalog
In Vitro PROTAC 包含两个不同的配体,通过一个接头连接;一个是 E3 泛素连接酶的配体,另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
References

[1]. Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.  

 Chemical & Physical Properties

Molecular Formula C41H45Cl3N4O5
Molecular Weight 780.18