BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride structure
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Common Name | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride | ||
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CAS Number | 2691796-83-3 | Molecular Weight | 780.18 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C41H45Cl3N4O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of BMS-1166-N-piperidine-CO-N-piperazine dihydrochlorideBMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PD-1/PD-L1 degrader-1.html" class="link-product" target="_blank">PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1]. |
Name | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride |
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Description | BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PD-1/PD-L1 degrader-1.html" class="link-product" target="_blank">PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1]. |
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Related Catalog | |
In Vitro | PROTAC 包含两个不同的配体,通过一个接头连接;一个是 E3 泛素连接酶的配体,另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 |
References |
Molecular Formula | C41H45Cl3N4O5 |
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Molecular Weight | 780.18 |